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L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition Versluis, M. A. C. Plat, A. Bruyn, M. de Matias-Guiu, Xavier, 1958- Trovic, J. Krakstad, C. Nijman, H. W. Bosse, T. Bock, G. H. de Hollema, H. Malalties uterines Metàstasi Uterus diseases Metastasis Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial-mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAM is an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype. We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAM and scored in four categories (0%, <10%, 10-50%, and >50%). A score of more than 10% was considered positive for L1CAM. The median age at presentation was 68.6years, and half of the patients (53.3%) presented with FIGO stage 1 disease. Membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAM and keratin. Expression of L1CAM did not relate to overall or disease-free survival. Our findings suggest L1CAM is either not a marker for the mesenchymal phenotype in EMT, or UCS is not a good model for EMT. 2020-11-17T08:14:29Z 2020-11-17T08:14:29Z 2018-11-01 2020-11-11T17:38:47Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1007/s00428-018-2444-8 Virchows Archiv, 2018, vol. 473, num. 5, p. 591-598 https://doi.org/10.1007/s00428-018-2444-8 cc by (c) Versluis et al., 2018 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Springer Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))