2026-04-13T01:42:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1719432025-12-05T09:35:14Zcom_2072_1057col_2072_478798col_2072_478799col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Guerrero Pérez, Fernando author Casajoana, Anna author Gómez Vaquero, Carmen author Virgili, Núria author López Urdiales, Rafael author Hernández Montoliu, Laura author Pujol Gebelli, Jordi author Osorio, Javier author Prats, Anna author Pujol Gebelli, Jordi author Pérez Maraver, Manuel author Fernández Veledo, Sonia author Vendrell, Joan author Vilarrasa, Nuria author 2020-11-10T12:11:38Z 2020-11-10T12:11:38Z 2020-06-01 2020-11-03T17:11:50Z There is scant evidence of the long-term effects of bariatric surgery on bone mineral density (BMD). We compared BMD changes in patients with severe obesity and type 2 diabetes (T2D) 5 years after randomization to metabolic gastric bypass (mRYGB), sleeve gastrectomy (SG) and greater curvature plication (GCP). We studied the influence of first year gastrointestinal hormone changes on final bone outcomes. Forty-five patients, averaging 49.4 (7.8) years old and body mass index (BMI) 39.4 (1.9) kg/m(2), were included. BMD at lumbar spine (LS) was lower after mRYGB compared to SG and GCP: 0.89 [0.82;0.94] vs. 1.04 [0.91;1.16] vs. 0.99 [0.89;1.12],p= 0.020. A higher percentage of LS osteopenia was present after mRYGB 78.6% vs. 33.3% vs. 50.0%, respectively. BMD reduction was greater in T2D remitters vs. non-remitters. Weight at fifth year predicted BMD changes at the femoral neck (FN) (adjustedR(2): 0.3218;p= 0.002), and type of surgery (mRYGB) and menopause predicted BMD changes at LS (adjustedR(2): 0.2507;p< 0.015). In conclusion, mRYGB produces higher deleterious effects on bone at LS compared to SG and GCP in the long-term. Women in menopause undergoing mRYGB are at highest risk of bone deterioration. Gastrointestinal hormone changes after surgery do not play a major role in BMD outcomes. Densitat mineral òssia Cirurgia de l'obesitat Bone density Obesity surgery Long-term effects in bone mineral density after different bariatric procedures in patients with type 2 diabetes: outcomes of a randomized clinical trial