2026-04-13T16:54:35Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1716862025-12-04T21:11:25Zcom_2072_1057col_2072_478781col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Serrano Novillo, Clara author Capera Aragonés, Jesusa author Colomer-Molera, Magalí author Condom i Mundó, Enric author Ferreres, Joan C. author Felipe Campo, Antonio author 2020-11-02T12:28:46Z 2020-11-02T12:28:46Z 2019-03-01 2020-11-02T12:28:46Z Voltage-gated potassium channels (Kv) are the largest group of ion channels. Kv are involved in controlling the resting potential and action potential duration in the heart and brain. Additionally, these proteins participate in cell cycle progression as well as in several other important features in mammalian cell physiology, such as activation, differentiation, apoptosis, and cell volume control. Therefore, Kv remarkably participate in the cell function by balancing responses. The implication of Kv in physiological and pathophysiological cell growth is the subject of study, as Kv are proposed as therapeutic targets for tumor regression. Though it is widely accepted that Kv channels control proliferation by allowing cell cycle progression, their role is controversial. Kv expression is altered in many cancers, and their participation, as well as their use as tumor markers, is worthy of effort. There is an ever-growing list of Kv that remodel during tumorigenesis. This review focuses on the actual knowledge of Kv channel expression and their relationship with neoplastic proliferation. In this work, we provide an update of what is currently known about these proteins, thereby paving the way for a more precise understanding of the participation of Kv during cancer development. Càncer Cicle cel·lular Proliferació cel·lular Cancer Cell cycle Cell proliferation Implication of voltage-gated potassium channels in neoplastic cell proliferation