2026-04-17T21:27:16Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1713692025-12-05T14:25:23Zcom_2072_1057col_2072_478777col_2072_478816col_2072_478917

00925njm 22002777a 4500 dc Castro-Torres, Rubén Darío author Busquets Figueras, Oriol author Parcerisas, Antoni author Verdaguer Cardona, Ester author Olloquequi, Jordi author Ettcheto Arriola, Miren author Beas Zárate, Carlos author Folch, Jaume author Camins Espuny, Antoni author Auladell i Costa, M. Carme author 2020-10-19T18:32:00Z 2020-10-19T18:32:00Z 2020-08-13 2020-10-19T18:32:01Z The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS. Proteïnes quinases Evolució del cervell Protein kinases Evolution of the brain Involvement of JNK1 in neuronal polarization during brain development