2026-04-13T15:05:09Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1711342025-12-05T16:23:47Zcom_2072_1057col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Quattrone, Diego author Di Forti, Marta author Gayer-Anderson, Charlotte author Ferraro, Laura author Jongsma, Hanna E. author Tripoli, Giada author La Cascia, Caterina author La Barbera, Daniele author Tarricone, Ilaria author Berardi, Domenico author Szöke, Andrei author Arango, Celso author Lasalvia, Antonio author Tortelli, Andrea author Llorca, Pierre Michel author de Haan, Lieuwe author Velthorst, Eva author Bobes García, Julio author Bernardo Arroyo, Miquel author Sanjuán, Julio author Arrojo, Manuel author Del-Ben, Cristina Marta author Menezes, Paulo Rossi author Selten, Jean Paul author EU-GEI WP2 Group author Jones, Peter B. author Kirkbride, James B. author Richards, Alexander L. author O'Donovan, Michael C. author Sham, Pak C. author Vassos, Evangelos author Rutten, Bart P.F. author van Os, Jim author Morgan, Craig author Lewis, Cathryn M. author Murray, Robin M. author Reininghaus, Ulrich author 2020-10-08T15:30:12Z 2020-10-08T15:30:12Z 2019-07-24 2020-10-08T15:30:12Z Background: The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment. Method: This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions. Results: A bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-first-contact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions. Conclusions: Our results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum. Psicosi Esquizofrènia Psicopatologia Psychoses Schizophrenia Pathological psychology Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinacional EU-GEI study