2026-04-13T07:23:02Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1697132025-12-05T14:33:12Zcom_2072_1057col_2072_478917col_2072_478923
RECERCAT
author
Valente, A.
author
Santos, A.M.
author
Côrte-Real, L.
author
Robalo, M.P.
author
Moreno Martínez, Virtudes
author
Font Bardia, Ma. Mercedes
author
Calvet Pallàs, Maria Teresa
author
Lorenzo, Julia
author
Garcia, M.E.
2020-07-30T17:10:56Z2020-07-30T17:10:56Z2014-04-152020-07-30T17:10:56Z
A new family of 'FeII(h5-C5H5)' half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UVeVis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin.
(c) Elsevier B.V., 2014 info:eu-repo/semantics/openAccess
Compostos organometàl·lics
Cèl·lules canceroses
Apoptosi
Organometallic compounds
Cancer cells
Apoptosis
New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion