2026-04-18T04:45:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1665422025-11-20T14:36:17Zcom_2072_1057col_2072_478913col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Garza Puentes, Andrea de la author Martí Alemany, Adrià author Chisaguano Tonato, Aida Maribel author Montes Goyanes, Rosa author Castellote Bargalló, Ana Isabel author Torres Espinola, Francisco José author García-Valdés, Luz author Escudero-Marín, Mireia author Segura Moreno, Maite author Campoy, Cristina author López Sabater, María del Carmen author 2020-06-25T08:43:14Z 2020-06-25T08:43:14Z 2019-09-09 2020-06-25T08:43:14Z This study analyzed how maternal obesity a ected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming e ect of maternal health and to promote a healthy prenatal weight. Mother-child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5-24.99), overweight (BMI = 25-29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased -linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and negatively a ected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy weight in future generations. Llet materna Creixement Obesitat Àcids grassos omega-3 Cognició Desenvolupament infantil Breast milk Growth Obesity Omega-3 fatty acids Cognition Child development The effect of maternal obesity on breast milk fatty acids and its association with infant growth and cognition-The Preobe follow-up