2026-04-14T06:21:07Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1652882025-12-05T14:33:45Zcom_2072_1057col_2072_478917col_2072_478923
RECERCAT
author
Prohens López, Rafael
author
Barbas Cañero, Rafael
author
Portell Bueso, Anna
author
Font Bardia, Ma. Mercedes
author
Alcobé i Ollé, Xavier
author
Puigjaner Vallet, Ma. Cristina
2020-06-12T07:17:10Z2020-06-12T07:17:10Z20152020-06-12T07:17:10Z
The solid state of adefovir dipivoxil (AD) has been revisited. In the present article we extend the knowledge about the solid state of this pharmaceutical prodrug. The stability landscape of the amorphous form with respect to the anhydrous and hydrate crystalline forms has been studied, and the use of an antiplasticizing agent to increase its Tg is described. The crystal structure of the elusive anhydrous form I has been determined from laboratory powder X-ray diffraction data by means of direct space methods using the computing program FOX. In addition, three new isostructural solvates of AD (methanol, ethylenglycol, and methylethylketone) have been discovered and structurally characterized by single cristal X-ray diffraction.
(c) American Chemical Society , 2015 info:eu-repo/semantics/openAccess
Estructura cristal·lina (Sòlids)
Medicaments antivírics
Layer structure (Solids)
Antiviral agents
Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion