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oai:recercat.cat:2445/1652322025-12-04T20:36:18Zcom_2072_1057col_2072_478800col_2072_478917

1H-NMR Urinary Metabolic Profile, A Promising Tool for the Management of Infants with Human Cytomegalovirus-Infection Frick, Marie Antoinette Barba, Ignasi Fenoy-Alejandre, Marina López-López, Paula Baquero Artigao, Fernando Rodríguez-Molino, Paula Noguera Julian, Antoni Nicolás-López, Marta de la Fuente-Juárez, Asunción Codina Grau, Maria Gemma Esperalba Esquerra, Juliana Linde-Sillo, Ángeles Soler Palacín, Pere Infeccions per citomegalovirus Pediatria Metabolòmica Cytomegalovirus infections Pediatrics Metabolomics Abstract: Congenital human cytomegalovirus (HCMV) infection is the most common mother-to-child transmitted infection in the developed world. Certain aspects of its management remain a challenge. Urinary metabolic profiling is a promising tool for use in pediatric conditions. The aim of this study was to investigate the urinary metabolic profile in HCMV-infected infants and controls during acute care hospitalization. Urine samples were collected from 53 patients at five hospitals participating in the Spanish congenital HCMV registry. Thirty-one cases of HCMV infection and 22 uninfected controls were included. Proton nuclear magnetic resonance (1H-NMR) spectra were obtained using NOESYPR1D pulse sequence. The dataset underwent orthogonal projection on latent structures discriminant analysis to identify candidate variables affecting the urinary metabolome: HCMV infection, type of infection, sex, chronological age, gestational age, type of delivery, twins, and diet. Statistically significant discriminative models were obtained only for HCMV infection (p = 0.03) and chronological age (p < 0.01). No significant differences in the metabolomic profile were found between congenital and postnatal HCMV infection. When the HCMV-infected group was analyzed according to chronological age, a statistically significant model was obtained only in the neonatal group (p = 0.01), with the differentiating metabolites being betaine, glycine, alanine, and dimethylamine. Despite the considerable variation in urinary metabolic profiles in a real-life setting, clinical application of metabolomics to the study of HCMV infection seems feasible. 2020-06-11T21:32:33Z 2020-06-11T21:32:33Z 2019-11-15 2020-06-11T21:32:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2218-1989 https://hdl.handle.net/2445/165232 693744 31775291 eng Reproducció del document publicat a: https://doi.org/10.3390/metabo9120288 Metabolites, 2019, vol. 9, p. 288 https://doi.org/10.3390/metabo9120288 cc-by (c) Frick, Marie Antoinette et al., 2019 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess 14 p. application/pdf MDPI Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)