2026-04-18T00:30:57Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1644332025-12-04T22:54:30Zcom_2072_1057col_2072_478782col_2072_478913col_2072_478917

00925njm 22002777a 4500 dc Ruiz Iglesias, Patricia author Estruel Amades, Seila author Camps i Bossacoma, Mariona author Massot Cladera, Malen author Franch i Masferrer, Àngels author Pérez-Cano, Francisco J. author Castell, Margarida author 2020-06-05T09:43:55Z 2020-06-05T09:43:55Z 2020-05-01 2020-06-05T09:43:55Z Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive e ects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the e ect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alteration. Exercici Fatiga Cèl·lules K Sistema immunitari Estrès oxidatiu Sang Rates (Animals de laboratori) Melsa Macròfags Fagocitosi Exercise Fatigue Killer cells Immune system Oxidative stress Blood Rats as laboratory animals Spleen Macrophages Phagocytosis Influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise