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A practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines Amat Tusón, Mercedes Navío, Laura Llor Brunés, Núria Molins, Elies Bosch Cartes, Joan Síntesi orgànica Lactames Enantiòmers Compostos heterocíclics Organic synthesis Lactams Enantiomers Heterocyclic compounds Starting from 4-substituted cyclohexanones, a practical synthetic route to enantiopure 6-substituted cis-decahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of an unsaturated δ-keto ester derivative with (R)-phenylglycinol and the stereoselective hydrogenation of the resulting tricyclic oxazoloquinolone lactams. 2020-06-03T09:40:22Z 2020-06-03T09:40:22Z 2012-01-06 2020-06-03T09:40:22Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1523-7060 https://hdl.handle.net/2445/164139 603300 22133083 eng Versió postprint del document publicat a: https://doi.org/10.1021/ol2030058 Organic Letters, 2012, vol. 14, num. 1, p. 210-213 https://doi.org/10.1021/ol2030058 (c) American Chemical Society , 2012 info:eu-repo/semantics/openAccess 4 p. application/pdf application/pdf American Chemical Society Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)