2026-04-13T18:20:56Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1640592025-11-20T14:36:14Zcom_2072_1057col_2072_478913col_2072_478917col_2072_478924
RECERCAT author Khymenets, Olha author Crespo, M. Carmen author Dangles, Olivier author Rakotomanomana, N. author Andrés Lacueva, Ma. Cristina author Visioli, F. (Francesco) 2020-06-03T07:11:22Z2020-06-03T07:11:22Z2016-03-312020-06-03T07:11:22Z Among the various (poly)phenols that are being sold as such or as part of a more complex mixture, hydroxytyrosol (HT) is the only one that bears a European Food Safety Authority health claim. Therefore, several HT-based products are being developed and sold and it becomes necessary to evaluate its accessibility following ingestion. Twenty-one volunteers were recruited for a randomized, crossover, placebo-controlled, and double-blind intervention study.We performed a Latin square design: after one-week washout, i.e. olive-free diet, subjects were randomly assigned to the placebo (maltodextrin), 5, or 25 mg/day HT group. Twenty-four hour urine samples were collected after the intervention week, and baseline urines were collected the week before the study and during periods of washout. The results show that HT given as the foremost component of a nutraceutical preparation is bioavailable and is recovered in the urine chiefly as sulphate-3′. cc-by-nc-nd (c) Khymenets, Olha et al., 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess Salut Suplements nutritius Espectrometria de masses Biodisponibilitat Assaigs clínics Metabòlits Polifenols Orina Health Dietary supplements Mass spectrometry Bioavailability Clinical trials Metabolites Polyphenols Urine Human hydroxytyrosol's absorption and excretion from a nutraceutical info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion