2026-04-13T02:22:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1640572025-12-05T10:52:49Zcom_2072_1057col_2072_478913col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Khymenets, Olha author Rabassa Bonet, Montserrat author Rodríguez-Palmero Seuma, María author Rivero Urgell, M. Montserrat author Urpí Sardà, Mireia author Tulipani, Sara author Brandi, P. author Campoy Folgoso, Cristina author Santos-Buelga, Celestino author Andrés Lacueva, Ma. Cristina author 2020-06-03T06:33:51Z 2020-06-03T06:33:51Z 2016-07-06 2020-06-03T06:33:51Z Polyphenols play an important role in human health. To address their accessibility to a breastfed infant, we planned to evaluate whether breast milk (BM) (colostrum, transitional, and mature) epicatechin metabolites could be related to the dietary habits of mothers. The polyphenol consumption of breastfeeding mothers was estimated using a food frequency questionnaire and 24 h recalls. Solid-phase extraction-ultra performance liquid chromatography-tandem mass spectrometry (SPE-UPLC-MS/MS) was applied for direct epicatechin metabolite analysis. Their bioavailability in BM as a result of dietary ingestion was confirmed in a preliminary experiment with a single dose of dark chocolate. Several host and microbial phase II metabolites of epicatechin were detected in BM among free-living lactating mothers. Interestingly, a modest correlation between dihydroxyvalerolactone sulfate and the intake of cocoa products was observed. Although a very low percentage of dietary polyphenols is excreted in BM, they are definitely in the diet of breastfed infants. Therefore, evaluation of their role in infant health could be further promoted. Alletament Infants Hàbits alimentaris Salut Cacau Polifenols Llet materna Metabolisme Espectrometria de masses Breastfeeding Children Food habits Health Cocoa Polyphenols Breast milk Metabolism Mass spectrometry Dietary Epicatechin Is Available to Breastfed Infants through Human Breast Milk in the Form of Host and Microbial Metabolites