2026-04-17T05:49:57Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1625772025-12-05T10:53:21Zcom_2072_1057col_2072_478913col_2072_478917col_2072_478924
RECERCAT
author
Martínez Garza, Úrsula
author
Torres-Oteros, Daniel
author
Yarritu-Gallego, Alex
author
Marrero González, Pedro F.
author
Haro Bautista, Diego
author
Relat Pardo, Joana
2020-05-27T07:55:24Z2020-05-27T07:55:24Z2019-09-212020-05-27T07:55:25Z
The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate metabolism. FGF21 response is essential under stressful conditions and its metabolic effects depend on the inducer factor or stress condition. FGF21 seems to be the key signal which communicates and coordinates the metabolic response to reverse different nutritional stresses and restores the metabolic homeostasis. This review is focused on describing individually the FGF21-dependent metabolic response activated by some of the most common nutritional challenges, the signal pathways triggering this response, and the impact of this response on global homeostasis. We consider that this is essential knowledge to identify the potential role of FGF21 in the onset and progression of some of the most prevalent metabolic pathologies and to understand the potential of FGF21 as a target for these diseases. After this review, we conclude that more research is needed to understand the mechanisms underlying the role of FGF21 in macronutrient preference and food intake behavior, but also in β-klotho regulation and the activity of the fibroblast activation protein (FAP) to uncover its therapeutic potential as a way to increase the FGF21 signaling.
cc-by (c) Martínez Garza, Úrsula et al., 2019 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Metabolisme
Glúcids
Obesitat
Expressió gènica
Resistència a la insulina
Fisiologia
Homeòstasi
Proteïnes de membrana
Teixit adipós
Hàbits alimentaris
Metabolism
Glucides
Obesity
Gene expression
Insulin resistance
Physiology
Homeostasis
Membrane proteins
Adipose tissues
Food habits
Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges.
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion