2026-04-17T01:06:08Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1623122025-12-04T19:36:01Zcom_2072_1057col_2072_478813col_2072_478917
RECERCAT author Ramos Romero, Sara author Hereu, Mercè author Atienza, Lidia author Casas, Josefina author Taltavull, Núria author Romeu Ferran, Marta author Amézqueta, Susana author Dasilva, Gabriel author Medina, Isabel author Torres, Josep Lluís 2020-05-25T14:31:59Z2020-05-25T14:31:59Z20182020-05-25T14:32:00Z Scope: The goals of this work were to test if D-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. Methods and results: Wistar Kyoto rats were fed a high-fat diet supplemented with D7 fagomine (or not; for comparison) or a standard diet (controls) for 24 weeks. The variables measured were: fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue, liver and muscle; inflammation markers (plasma IL-6 and leptin, and liver and adipose tissue histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales and Bifidobacteriales in feces. We found that D-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 and leukotriene B4) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales. Conclusion: D-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of D-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria. (c) Wiley-VCH, 2018 info:eu-repo/semantics/openAccess Microbiota Diabetis Obesitat Microbiota Diabetes Obesity Functional effects of the buckwheat iminosugar D-fagomine on rats with diet-induced prediabetes info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion