2026-04-17T05:39:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1623102025-12-04T19:37:51Zcom_2072_1057col_2072_478813col_2072_478917

00925njm 22002777a 4500 dc Hereu, Mercè author Ramos Romero, Sara author García-González, Natalia author Amézqueta, Susana author Torres, Josep Lluís author 2020-05-25T14:22:41Z 2020-05-25T14:22:41Z 2018-09-16 2020-05-25T14:22:41Z Diversity and balance of gut microorganisms is fundamental for health throughout life. The aim of this study is to explore the possible eubiotic effect of the buckwheat iminosugar D-fagomine (0.096% w/w in standard feed) in growing healthy Wistar Kyoto rats. Feed and energy intake, residual energy in feces, and body weight gain were independent of D-fagomine supplementation throughout the intervention (24 weeks). The populations of significant bacterial subgroups and species were determined in fecal and cecal DNA by quantitative real-time PCR. D-Fagomine increased the Bacteroidetes:Firmicutes ratio and partially counteracted the loss of Lactobacilliales and Bifidobacteriales over time. The supplementation reduced the levels of excreted short- chain fatty acids (SCFAs) as determined by gas chromatography. This paper provides preliminary evidence that D-fagomine has the capacity to promote microbial functional diversity by increasing the Bacteroidetes:Firmicutes ratio and to mitigate the age-related reduction in populations of the putatively beneficial Lactobacilliales and Bifidobacteriales. Lactobacils Microbiota Bifidobacteris Lactobacillus Microbiota Bifidobacterium Eubiotic effect of buckwheat D-fagomine in healthy rats