2026-04-13T01:35:31Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1620442025-12-04T20:37:34Zcom_2072_1057col_2072_478800col_2072_478858col_2072_478917
RECERCAT author Castelo-Branco Flores, Camil author Cancelo Hidalgo, M. J. author Palacios Ruiz, Lucas Santiago author Ciria Recasens, M. author Fernández Pareja, A. author Carbonell Abella, Cristina author Manasanch, J. author Haya Palazuelos, J. 2020-05-22T12:36:23Z2020-05-22T12:36:23Z2019-11-212020-05-22T12:36:23Z Objective: This study aimed to compare the efficacy and safety of ossein-hydroxyapatite complex (OHC) versus calcium carbonate (CC) for preventing bone loss during perimenopause in current clinical practice.Methods: The prospective, comparative, non-randomized, open-label study included 851 perimenopausal women with basal bone mineral density (BMD) T-score ≥-2 standard deviations (SDs). Participants received either OHC (712 mg calcium/day) or CC (1000 mg calcium/day) over 3 years. BMD was evaluated by dual-energy X-ray absorptiometry at the lumbar spine (L2-L4) at baseline and after 18 and 36 months of follow-up. Adverse drug reactions (ADRs) were also recorded.Results: In women receiving OHC, BMD at the L2-L4 site remained stable over the 3-year follow-up period (mean [SD] change 0.00 [0.11] g/cm2). BMD in the CC arm decreased -3.1% (mean [SD] - 0.03 [0.11] g/cm2). Between-group differences were statistically significant (p < 0.001) and favored OHC. ADRs were more frequent in the CC group (7.7% vs. 2.7% in the OHC group; p = 0.001), affecting primarily the gastrointestinal system.Conclusion: OHC showed greater efficacy and tolerability than CC for bone loss prevention in perimenopausal women in real-world practice. As the daily dose of calcium was higher in the CC group, the differences might be linked to the ossein compound in OHC. (c) The Author(s), 2020 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Menopausa Densitometria òssia Osteoporosi Menopause Bone densitometry Osteoporosis Efficacy and safety of ossein-hydroxyapatite complex versus calcium carbonate to prevent bone loss info:eu-repo/semantics/article