2026-04-17T12:54:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1603972025-11-19T21:40:48Zcom_2072_1057col_2072_478825col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Madrid Gambín, Francisco Javier author Garcia Aloy, Mar author Vázquez Fresno, Rosa author Vegas Lozano, Esteban author Sànchez, Àlex (Sànchez Pla) author Misawa, Kohichi author Hase, Tadashi author Shimotoyodome, Akira author Andrés Lacueva, Ma. Cristina author 2020-05-15T06:39:30Z 2020-05-15T06:39:30Z 2018-12-21 2020-05-15T06:39:32Z Functional tea beverages have emerged as a novel approach to achieving health benefits associated with tea. The use of metabolomics may improve the evaluation of their consumption and their effects. The current study aimed to explore the urinary signature of the exposure to a functional high-catechin tea (HCT) using untargeted NMR-based metabolomics. Ten volunteers participated in a crossover intervention study. Individuals consumed an HCT or a control beverage over a period of 28 days. Multilevel partial least squares discriminant analysis (ML-PLS-DA) was used for paired comparisons. A further crossover model was performed to assess the significant changes. The consumption of the HCT resulted in the excretion of theanine, epicatechin, pyrogallol sulfate, higher levels of 3-methyl-2-oxovalerate and succinate, as well as unknown compounds. In conclusion, the present work established novel urinary signatures of a functional drink. Such signatures may be potential biomarkers and/or reflect certain benefits of functional tea beverages. Marcadors bioquímics Te Metabòlits Orina Anàlisi discriminant Espectroscòpia de ressonància magnètica nuclear Biochemical markers Tea Metabolites Urine Discriminant analysis Nuclear magnetic resonance spectroscopy Metabolic signature of a functional high-catechin tea after acute and sustained consumption in healthy volunteers through 1H NMR-based metabolomics analysis of urine.