2026-04-17T22:52:21Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1599882025-12-05T14:11:46Zcom_2072_1057col_2072_478815col_2072_478917
RECERCAT
author
Salim, Norazlinaliza
author
García Celma, Ma José
author
Escribano Ferrer, Elvira
author
Nolla, Jordi
author
Llinàs, Meritxell
author
Basri, Mahiran
author
Solans Marsà, Conxita
author
Esquena, Jordi
author
Tadros, Tharwat F.
2020-05-13T16:07:51Z2020-05-13T16:07:51Z2018-01-012020-05-13T16:07:52Z
This study reports the formation of nanoemulsions from palm-kernel oil esters (PKOE)/Cremophor EL/water systems intended for topical administration of a non-steroidal anti-inflammatory drug, ibuprofen. Nanoemulsions containing 2% ibuprofen, various oil:surfactant ratios (10:90, 20:80 and 30:70) and 80% of water were selected from the ternary system of PKOE/Cremophor EL/water and prepared by the phase inversion composition (PIC) method. The characterization of the nanoemulsions such as droplet size, polydispersity index, zeta potential, stability and the permeation of ibuprofen from nanoemulsions were evaluated. The prepared nanoemulsions exhibited good stability without any phase separation, sedimentation or creaming for the period of tested experimental time (6 months). The permeation study of ibuprofen was performed on Franz type-diffusion cells through human abdominal skin. The median values of the fluxes obtained as well as the median of the percentage of permeated amount at 24h were not statistically different. The mean profiles of permeated ibuprofen versus time from PKOE was greater (p < 0.05) than those obtained from Miglyol 812.
cc-by-nc-nd (c) Salim, Norazlinaliza et al., 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess
Nanofluids
Antiinflamatoris no esteroïdals
Nanofluids
Nonsteroidal anti-inflammatory agents
Formation of nanoemulsion containing ibuprofen by PIC method for topical delivery
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion