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Role of a Polyphenol-Rich Dietary Pattern in the Modulation of Intestinal Permeability in Older Subjects: The MaPLE Study Bernardi, Stefano Bo', Cristian Del Guglielmetti, Simone Cherubini, Antonio Kroon, Paul A. Kirkup, Benjamin Hidalgo Liberona, Nicole Peron, Gregorio González-Domínguez, Raúl Andrés Lacueva, Ma. Cristina Riso, Patrizia Malalties cròniques Persones grans Malalties inflamatòries intestinals Chronic diseases Older people Inflammatory bowel diseases The inevitable rise of the proportion of people aged >65 years worldwide is paralleled by an increased burden of chronic diseases often associated with low-grade systemic inflammation. Recent findings suggest a link between inflammation and intestinal permeability (IP), a condition characterized by an impairment of intestinal barrier function which enables the translocation of dietary and bacterial factors into the blood activating the host immune system [1,2]. Dietary components can be significant modulators of inflammation and IP, and can also affect the intestinal microbial ecosystem. In the context of a diet-microbiota-IP axis in older subjects, dietary bioactives such as polyphenols may play a significant protective role due to their widely reported antioxidant and immunomodulatory properties and potential to regulate IP [3-6]. 2020-05-12T15:23:27Z 2020-05-12T15:23:27Z 2019-08-16 2020-05-12T15:23:27Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/proceedings2019011008 MDPI Proceedings, 2019, vol. 11, num. 8 https://doi.org/10.3390/proceedings2019011008 cc-by (c) Bernard, Stefano et al., 2019 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)