2026-04-13T06:35:32Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1588772025-11-19T20:35:22Zcom_2072_1057col_2072_478796col_2072_478917
RECERCAT
author
Pitulice, Laura
author
Vilaseca i Font, Eudald
author
Isvoran, Adriana
author
Garcés, Josep Lluís
author
Mas i Pujadas, Francesc
2020-05-06T08:48:35Z2020-05-06T08:48:35Z2011-06-232020-05-06T08:48:35Z
Using Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulation data are analyzed in terms of parameters describing the time dependence of the rate coefficient. Our results indicate a fractal like kinetics with different degrees of fractality depending on crowders features. Even though small, when crowders mobility rises kinetics fractality decreases due to enhancement of diffusional movements of the reactants. Instead, increasing the crowders density in the system kinetics fractality presents a smooth growth as less free volume is available for reactants.
(c) Universitatea de Vest din Timişoara, 2011 info:eu-repo/semantics/openAccess
Mètode de Montecarlo
Mètodes de simulació
Cinètica enzimàtica
Monte Carlo method
Simulation methods
Enzyme kinetics
Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion