2026-04-17T06:01:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1586042025-12-05T09:22:02Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Caja Puigsubirà, Laia author Dituri, Francesco author Mancarella, Serena author Caballero-Diaz, Daniel author Moustakas, Aristidis author Giannelli, Gianluigi author Fabregat Romero, Isabel author 2020-05-04T21:14:05Z 2020-05-04T21:14:05Z 2018-04-26 2020-05-04T21:14:06Z Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic response and for the activation of the cancer stroma. Strong evidence suggests that a strong cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is stored in the matrix as part of a large latent complex bound to the latent TGF-β binding protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix remodelling and promotes a fibroblast to myofibroblast transition, which is essential in fibrotic processes. This cytokine also acts on other cell types present in the fibrotic and tumour microenvironment, such as epithelial, endothelial cells or macrophages and it contributes to the cancer-associated fibroblast (CAF) phenotype. Furthermore, TGF-β exerts anti-tumour activity by inhibiting the host tumour immunosurveillance. Aim of this review is to update how TGF-β and the tissue microenvironment cooperate to promote the pleiotropic actions that regulate cell responses of different cell types, essential for the development of fibrosis and tumour progression. We discuss recent evidences suggesting the use of TGF-β chemical inhibitors as a new line of defence against fibrotic disorders or cancer. Càncer Fibrosi quística Matriu extracel·lular Cèl·lules K Cancer Cystic fibrosis Extracellular matrix Killer cells TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer