2026-04-14T06:09:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1576472025-12-04T21:42:04Zcom_2072_1057col_2072_478917col_2072_478933

Phakillestatins: an underwater unsolved puzzle Meli, Alessandra Tedesco, Consiglia Della Sala, Giorgio Schettini, Rosaria Albericio Palomera, Fernando de Riccardis, Francesco Izzo, Irene Aminoàcids Síntesi de pèptids Farmacologia Amino acids Peptide synthesis Pharmacology A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline‐rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various‐sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility. 2020-04-27T11:59:00Z 2020-04-27T11:59:00Z 2017-03-18 2020-04-27T11:59:00Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1660-3397 https://hdl.handle.net/2445/157647 681090 28335479 eng Reproducció del document publicat a: https://doi.org/10.3390/md15030078 Marine Drugs, 2017, vol. 15, num. 3, p. 78 https://doi.org/10.3390/md15030078 info:eu-repo/grantAgreement/EC/FP7/319011/EU//POMOS cc-by (c) Meli, Alessandra et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess 16 p. application/pdf MDPI Articles publicats en revistes (Química Inorgànica i Orgànica)