2026-04-17T03:58:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1573072025-12-05T13:17:22Zcom_2072_1057col_2072_478798col_2072_478858col_2072_478916col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Martínez Yélamos, Antonio author Saiz Hinarejos, Albert author Sánchez del Valle Díaz, Raquel author Casado Ruiz, Virginia author Ramon Torrell, Josep M. (Josep Maria) author Graus Ribas, Francesc author Arbizu Urdiain, Txomin author 2020-04-24T11:17:43Z 2020-04-24T11:17:43Z 2001-08-28 2020-04-24T11:17:43Z Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) > or =2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution. Líquid cefalorraquidi Esclerosi múltiple Proteïna-tirosina-fosfatasa Cerebrospinal fluid Multiple sclerosis Protein-tyrosine phosphatase 14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis