2026-04-17T03:22:20Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1561172025-12-05T14:18:13Zcom_2072_1057col_2072_478902col_2072_478917
OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity
Rovira, Xavier
Trapero, Ana
Pittolo, Silvia
Zussy, Charleine
Faucherre, Adèle
Jopling, Chris
Giraldo, Jesús
Pin, Jean-Philippe
Gorostiza Langa, Pablo Ignacio
Goudet, Cyril
Llebaria Soldevila, Amadeu
Sistema nerviós
Dolor crònic
Nervous system
Chronic pain
OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system.
2020-04-20T16:06:02Z
2020-04-20T16:06:02Z
2016-08-18
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
Cell Chemical Biology, 2016, vol. 23, num. 8 p. 929-934
https://doi.org/10.1016/j.chembiol.2016.06.013
info:eu-repo/grantAgreement/EC/H2020/785907/EU//HBP_SGA2
info:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1
info:eu-repo/grantAgreement/EC/FP7/270483/EU//FOCUS
info:eu-repo/grantAgreement/EC/FP7/335011/EU//THERALIGHT
info:eu-repo/grantAgreement/EC/FP7/210355/EU//OPTICALBULLET
cc by-nc-nd (c) Elsevier, 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
Elsevier
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))