2026-04-17T01:50:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1561172025-12-05T14:18:13Zcom_2072_1057col_2072_478902col_2072_478917

00925njm 22002777a 4500 dc Rovira, Xavier author Trapero, Ana author Pittolo, Silvia author Zussy, Charleine author Faucherre, Adèle author Jopling, Chris author Giraldo, Jesús author Pin, Jean-Philippe author Gorostiza Langa, Pablo Ignacio author Goudet, Cyril author Llebaria Soldevila, Amadeu author 2020-04-20T16:06:02Z 2020-04-20T16:06:02Z 2016-08-18 OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system. Sistema nerviós Dolor crònic Nervous system Chronic pain OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity