2026-04-17T06:05:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1560832025-11-19T11:03:57Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Martini, Daniela author Chiavaroli, Laura author González-Sarrías, Antonio author Bresciani, Letizia author Palma-Duran, Susana A. author Dall'Asta, Margherita author Deligiannidou, Georgia-Eirini author Massaro, Marika author Scoditti, Egeria author Combet, Emilie author Maksimova, Viktorija author Urpí Sardà, Mireia author Kontogiorgis, Christos A. author Andrés Lacueva, Ma. Cristina author Gibney, Eileen R. author Del Rio, Daniele author Morand, Christine author Garcia Aloy, Mar author Rodriguez-Mateos, Ana author Mena, Pedro author 2020-04-20T14:57:37Z 2020-04-20T14:57:37Z 2019-08-05 2020-04-20T14:57:38Z Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790. Vegetarianisme Compostos bioactius Polifenols Malalties cardiovasculars Vegetarianism Bioactive compounds Polyphenols Cardiovascular diseases Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability