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Investigation of the N-terminus amino functional of Arg10-Teixobactin Abdel Monaim, Shimaa A. H. Noki, Sikabwe Ramchuran, Estelle J. El-Faham, Ayman Albericio Palomera, Fernando de la Torre, Beatriz G. Síntesi de pèptids Bacteris Mycobacterium tuberculosis Peptide synthesis Bacteria Mycobacterium tuberculosis Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity. 2020-04-14T20:47:11Z 2020-04-14T20:47:11Z 2017-09-28 2020-04-14T20:47:12Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/molecules22101632 Molecules, 2017, vol. 22, num. 10, p. 1632 https://doi.org/10.3390/molecules22101632 cc-by (c) Abdel Monaim, Shimaa A. H. et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Química Inorgànica i Orgànica)