2026-04-13T04:55:13Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1553112025-12-04T21:40:09Zcom_2072_1057col_2072_478917col_2072_478933
RECERCAT
author
Abdel Monaim, Shimaa A. H.
author
Noki, Sikabwe
author
Ramchuran, Estelle J.
author
El-Faham, Ayman
author
Albericio Palomera, Fernando
author
de la Torre, Beatriz G.
2020-04-14T20:47:11Z2020-04-14T20:47:11Z2017-09-282020-04-14T20:47:12Z
Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity.
cc-by (c) Abdel Monaim, Shimaa A. H. et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Síntesi de pèptids
Bacteris
Mycobacterium tuberculosis
Peptide synthesis
Bacteria
Mycobacterium tuberculosis
Investigation of the N-terminus amino functional of Arg10-Teixobactin
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion