2026-04-14T02:26:18Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1553112025-12-04T21:40:09Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Abdel Monaim, Shimaa A. H. author Noki, Sikabwe author Ramchuran, Estelle J. author El-Faham, Ayman author Albericio Palomera, Fernando author de la Torre, Beatriz G. author 2020-04-14T20:47:11Z 2020-04-14T20:47:11Z 2017-09-28 2020-04-14T20:47:12Z Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity. Síntesi de pèptids Bacteris Mycobacterium tuberculosis Peptide synthesis Bacteria Mycobacterium tuberculosis Investigation of the N-terminus amino functional of Arg10-Teixobactin