2026-04-17T18:47:28Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1549122025-12-04T21:42:22Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Caro, Carlos author Dalmases Solé, Mariona author Figuerola i Silvestre, Albert author García-Martín, M.L. author Pernia Leal, Manuel author 2020-04-03T11:35:55Z 2020-04-03T11:35:55Z 2017-04-25 2020-04-03T11:35:55Z X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that requires intravenously administration of contrast agents to enhance the sensitivity and visualization of soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles. A facile and gentle ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic as an anchor resulted in highly water-soluble and monodisperse nanoparticles. Moreover, the injected PEGylated ternary NPs presented excellent characteristics as a CT contrast agent with high bioavailability, low cytotoxicity and long blood circulation times with slow uptake by the mononuclear phagocyte system, thus being ideal for in vivo imaging. Lligands Nanopartícules Tomografia Ligands Nanoparticles Tomography Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood term X-rays computed tomography contrast agents