2026-04-13T05:59:18Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1528182025-11-19T19:23:58Zcom_2072_1057col_2072_478813col_2072_478917col_2072_478933
RECERCAT
author
Alguacil, Javier
author
Robles i Brau, Jordi
author
Ràfols Llach, Clara
author
Bosch, Elisabeth
2020-03-16T10:32:23Z2020-03-16T10:32:23Z20162020-03-16T10:32:24Z
Isothermal titration calorimetry (ITC) is a powerful technique able to evaluate the energetics of target-drug binding within the context of drug discovery. In this work, the interactions of RNAs reproducing bacterial and human ribosomal A-site, with two well-known antibiotic aminoglycosides, Paromomycin and Neomycin, as well as several Neomycin-dinucleotide and -diPNA conjugates, have been evaluated by ITC and the corresponding thermodynamic quantities determined. The comparison of the thermodynamic data of aminoglycosides and their chemical analogues allowed to select Neomycin-diPNA conjugates as the best candidates for antimicrobial activity.
(c) John Wiley & Sons, 2016 info:eu-repo/semantics/openAccess
Calorimetria
Antibiòtics
RNA
Termodinàmica
Calorimetry
Antibiotics
RNA
Thermodynamics
Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion