2026-04-13T01:08:13Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1525892025-12-04T21:27:12Zcom_2072_1057col_2072_478779col_2072_478917
RECERCAT
author
Andrade, Jean Paulo de
author
Berkov, Strahil
author
Viladomat Meya, Francesc
author
Codina Mahrer, Carles
author
Zuanazzi, José Ângelo Silveira
author
Bastida Armengol, Jaume
2020-03-11T17:22:44Z2020-03-11T17:22:44Z2011-08-182020-03-11T17:22:44Z
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
cc-by (c) Andrade, Jean Paulo de et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Alcaloides
Acetilcolinesterasa
Malaltia d'Alzheimer
Amaril·lidàcies
Alkaloids
Acetylcholinesterase
Alzheimer's disease
Amaryllidaceae
Alkaloids from Hippeastrum papilio
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion