2026-04-18T01:10:54Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1525892025-12-04T21:27:12Zcom_2072_1057col_2072_478779col_2072_478917

00925njm 22002777a 4500 dc Andrade, Jean Paulo de author Berkov, Strahil author Viladomat Meya, Francesc author Codina Mahrer, Carles author Zuanazzi, José Ângelo Silveira author Bastida Armengol, Jaume author 2020-03-11T17:22:44Z 2020-03-11T17:22:44Z 2011-08-18 2020-03-11T17:22:44Z Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine. Alcaloides Acetilcolinesterasa Malaltia d'Alzheimer Amaril·lidàcies Alkaloids Acetylcholinesterase Alzheimer's disease Amaryllidaceae Alkaloids from Hippeastrum papilio