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Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione Rodríguez Cabrera, Hortensia María Martin, Osnieski Suárez, Margarita Martín, Nazario Albericio Palomera, Fernando Escalfament per microones Molècules Química verda Calefacció Microwave heating Molecules Green chemistry Heating Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable dihydropyridine derivatives does not involve the harsh or highly contaminating conditions common in classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work-up procedures, facility of scale up, and low energy consumption, in addition to moderate to higher yields. 2020-03-11T17:16:37Z 2020-03-11T17:16:37Z 2011-11-21 2020-03-11T17:16:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1420-3049 https://hdl.handle.net/2445/152588 613934 22105712 eng Reproducció del document publicat a: https://doi.org/10.3390/molecules16119620 Molecules, 2011, vol. 16, num. 11, p. 9620-9635 https://doi.org/10.3390/molecules16119620 cc-by (c) Rodríguez, Hortensia et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess 16 p. application/pdf MDPI Articles publicats en revistes (Química Inorgànica i Orgànica)