2026-04-18T01:22:19Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1525882025-12-04T21:40:28Zcom_2072_1057col_2072_478917col_2072_478933
RECERCAT
author
Rodríguez Cabrera, Hortensia María
author
Martin, Osnieski
author
Suárez, Margarita
author
Martín, Nazario
author
Albericio Palomera, Fernando
2020-03-11T17:16:37Z2020-03-11T17:16:37Z2011-11-212020-03-11T17:16:37Z
Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable dihydropyridine derivatives does not involve the harsh or highly contaminating conditions common in classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work-up procedures, facility of scale up, and low energy consumption, in addition to moderate to higher yields.
cc-by (c) Rodríguez, Hortensia et al., 2011 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Escalfament per microones
Molècules
Química verda
Calefacció
Microwave heating
Molecules
Green chemistry
Heating
Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion