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oai:recercat.cat:2445/1525882025-12-04T21:40:28Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Rodríguez Cabrera, Hortensia María author Martin, Osnieski author Suárez, Margarita author Martín, Nazario author Albericio Palomera, Fernando author 2020-03-11T17:16:37Z 2020-03-11T17:16:37Z 2011-11-21 2020-03-11T17:16:37Z Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable dihydropyridine derivatives does not involve the harsh or highly contaminating conditions common in classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work-up procedures, facility of scale up, and low energy consumption, in addition to moderate to higher yields. Escalfament per microones Molècules Química verda Calefacció Microwave heating Molecules Green chemistry Heating Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione