2026-04-17T14:59:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1525832025-12-05T14:11:27Zcom_2072_1057col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Osorio Durango, Edison Javier author Londoño, Julián author Bastida Armengol, Jaume author 2020-03-11T16:11:47Z 2020-03-11T16:11:47Z 2013-05-22 2020-03-11T16:11:47Z Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant. Gutíferes Antioxidants Flavonoides Glucòsids Guttiferae Antioxidants Flavonoids Glucosides Low-density lipoprotein (LDL)-antioxidant biflavonoids from Garcinia madruno