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oai:recercat.cat:2445/1525832025-12-05T14:11:27Zcom_2072_1057col_2072_478815col_2072_478917

urn:hdl:2445/152583 Low-density lipoprotein (LDL)-antioxidant biflavonoids from Garcinia madruno Osorio Durango, Edison Javier Londoño, Julián Bastida Armengol, Jaume Gutíferes Antioxidants Flavonoides Glucòsids Guttiferae Antioxidants Flavonoids Glucosides Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant. 2020-03-11T16:11:47Z 2020-03-11T16:11:47Z 2013-05-22 2020-03-11T16:11:47Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/molecules18056092 Molecules, 2013, vol. 18, num. 5, p. 6092-6100 https://doi.org/10.3390/molecules18056092 cc-by (c) Osorio, Edison et al., 2013 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)