2026-04-14T05:50:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1525232025-12-04T19:33:04Zcom_2072_1057col_2072_478908col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Pelay Gimeno, Marta author Tulla-Puche, Judit author Albericio Palomera, Fernando author 2020-03-11T12:24:42Z 2020-03-11T12:24:42Z 2013-05-21 2020-03-11T12:24:43Z Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as "head-to-side-chain" cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein. Productes naturals Medicaments peptídics Poliquets Natural products Peptide drugs Polychaeta 'Head-to-side-chain' cyclodepsipeptides of marine origin