2026-04-13T05:59:17Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1525192025-12-04T21:44:25Zcom_2072_1057col_2072_478917col_2072_478933
RECERCAT
author
Andermark, Vincent
author
Göke, Katrin
author
Kokoschka, Malte
author
Abu el Maaty, Mohamed
author
Lumg, Chin Tung
author
Zoug, Taotao
author
Sun, Raymond Wai-Tin
author
Aguiló Linares, Elisabet
author
Oehninger, Luciano
author
Rodríguez Raurell, Laura
author
Bunjes, Heike
author
Wölfl, Stefan
author
Cheg, Chi-Ming
author
Ott, Ingo
2020-03-11T11:34:23Z2020-03-11T11:34:23Z2015-12-202020-03-11T11:34:23Z
The synthesis and characterization of four organometallic gold(I) complexes containing different water soluble phosphanes (TPPTS, PTA and DAPTA) and chromophoric units (4-pyridylethynyl and propargyloxycoumarin) is here reported. The analysis of their absorption and emission spectra led us to attribute their luminescent behaviour to the chromophoric organic ligands. Moreover, the presence of the gold(I) metal atom has been observed to be the responsible of an efficient intersystem crossing process responsible for the observed phosphorescence emission. Broad emission bands are observed in most cases due to the formation of organized aggregates in solution in agreement with microscopic characterization. Biological activity of the complexes showed very low effects against tumor cell growth but an inhibitory potency against thioredoxin reductase (TrxR). The missing / low cytotoxic effects could be related to a low bioavailability as determined by atomic absorption spectroscopy.
(c) Springer Verlag, 2015 info:eu-repo/semantics/openAccess
Càncer
Microarrays
Or
Cancer
Protein microarrays
Gold
Alkynyl gold(I) phosphane complexes: evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion