2026-04-17T08:03:17Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1513472025-11-19T20:41:12Zcom_2072_1057col_2072_478781col_2072_478917
RECERCAT
author
Buitrago Ospina, Diana Camila
author
Codó Tarraubella, Laia
author
Illa Pujagut, Ricard
author
Jorge, Pau de
author
Flores Guri, Oscar
author
Battistini, Federica
author
Bayarri, Genís
author
Royo, Romina
author
Del Pino, Marc
author
Heath, Simon C.
author
Hospital, Adam
author
Gelpí Buchaca, Josep Lluís
author
Brun Heath, Isabelle
author
Orozco López, Modesto
2020-02-27T14:54:12Z2020-02-27T14:54:12Z2019-08-312020-02-27T14:54:13Z
We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models.
cc-by-nc (c) Buitrago, Diana et al., 2019 http://creativecommons.org/licenses/by-nc/3.0/es info:eu-repo/semantics/openAccess
Cromatina
Bioinformàtica
Chromatin
Bioinformatics
Nucleosome Dynamics: A new tool for the dynamic analysis of nucleosome positioning
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion