2026-04-14T08:04:20Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1513472025-11-19T20:41:12Zcom_2072_1057col_2072_478781col_2072_478917

00925njm 22002777a 4500 dc Buitrago Ospina, Diana Camila author Codó Tarraubella, Laia author Illa Pujagut, Ricard author Jorge, Pau de author Flores Guri, Oscar author Battistini, Federica author Bayarri, Genís author Royo, Romina author Del Pino, Marc author Heath, Simon C. author Hospital, Adam author Gelpí Buchaca, Josep Lluís author Brun Heath, Isabelle author Orozco López, Modesto author 2020-02-27T14:54:12Z 2020-02-27T14:54:12Z 2019-08-31 2020-02-27T14:54:13Z We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models. Cromatina Bioinformàtica Chromatin Bioinformatics Nucleosome Dynamics: A new tool for the dynamic analysis of nucleosome positioning