2026-04-13T00:13:27Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1491372025-12-04T20:36:40Zcom_2072_1057col_2072_478800col_2072_478917
RECERCAT author Xargay i Torrent, Sílvia author Carreras Badosa, Gemma author Prats Puig, Anna author Soriano, Pilar author Álvarez Castaño, Elena author Ferri, María José author Borrat Padrosa, Sara author Zegher, Francis de author Ibáñez Toda, Lourdes author López Bermejo, Abel author Bassols, Judit 2020-01-31T08:57:16Z2020-01-31T08:57:16Z2018-10-152020-01-31T08:57:16Z Sex hormone-binding globulin (SHBG) negatively associates with pre-gestational body mass index (BMI) and gestational weight gain. The link with other cardio-metabolic risk factors in pregnant women is poorly understood. Our aim was to study the association of SHBG levels with common cardio-metabolic risk parameters in pregnant woman. Serum SHBG was quantified in 291 Caucasian pregnant women (142 with normal weight, 42 with pregestational obesity, 50 with gestational obesity and 57 with pregestational plus gestational obesity) with uncomplicated pregnancies and parturition. Cardio-metabolic [C-reactive protein (CRP), blood pressure (BP), glycosylated hemoglobin (HbAc1), glucose, C-peptide, insulin, triglycerides and high molecular weight (HMW) adiponectin], and endocrine [testosterone and estradiol] parameters were also assessed. SHBG was negatively correlated with BMI, but also with CRP, BP, HbAc1, pre and post-load glucose, C-peptide, HOMA-IR, triglycerides; and positively with HMW adiponectin (all p<0.01 to p<0.0001). These associations were more robust in women with pregestational plus gestational obesity, who had lower SHBG, in comparison to normal-weight women (p<0.0001). In multivariate analyses in women with pregestational plus gestational obesity SHBG showed independent associations with CRP (β = -0.352, p = 0.03, R2 = 8.0%), DBP (β = -0.353, p = 0.03, R2 = 7.0%) and SBP (β = -0.333, p = 0.04, R2 = 6.0%) independently of BMI and metabolic and endocrine parameters. SHBG is decreased in pregnant women with pregestational plus gestational obesity in association with common cardio-metabolic parameters. SHBG could represent an integrating biomarker for an adverse cardio-metabolic profile in pregnant women with pregestational plus gestational obesity. cc-by (c) Xargay Torrent, Sílvia et al., 2018 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Hormones sexuals Marcadors bioquímics Embarassades Cardiologia Obesitat Sex hormones Biochemical markers Pregnant women Cardiology Obesity Circulating sex hormone binding globulin: an integrating biomarker for an adverse cardio-metabolic profile in obese pregnant women info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion