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Evaluation of logPo/w values of drugs from some molecular structure calculation software Pallicer Santana, Juan Manuel Rosés Pascual, Martí Ràfols Llach, Clara Bosch, Elisabeth Pascual, Rosalía Port, Ariadna Lipofília Química farmacèutica Lipophilicity Pharmaceutical chemistry The iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187. 2019-10-28T17:49:39Z 2019-10-28T17:49:39Z 2014 2019-10-28T17:49:39Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1848-7718 https://hdl.handle.net/2445/143378 643435 eng Reproducció del document publicat a: https://doi.org/10.5599/admet.2.2.45 ADMET & DMPK, 2014, vol. 2, num. 2, p. 107-114 https://doi.org/10.5599/admet.2.2.45 cc-by (c) Pallicer Santana, Juan Manuel et al., 2014 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess 8 p. application/pdf application/pdf IAPC Publishing Articles publicats en revistes (Enginyeria Química i Química Analítica)