2026-04-17T03:32:39Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1417282025-12-05T10:07:24Zcom_2072_1057col_2072_478917col_2072_478929

00925njm 22002777a 4500 dc Cabré, Rosanna author Naudi, Alba author Domínguez González, Mayelín author Jove, Mariona author Ayala, Victòria author Mota-Martorell, Natalia author Portero-Otin, Manuel author Ferrer, Isidro (Ferrer Abizanda) author Pamplona, Reinald author Pradas, Irene author Nogueras, Lara author Rué, Montserrat author 2019-10-04T13:20:19Z 2019-10-04T13:20:19Z 2018-05-09 2019-10-04T13:20:19Z Fatty acids are key components in the structural diversity of lipids and play a strategic role in the functional properties of lipids which determine the structural and functional integrity of neural cell membranes, the generation of lipid signaling mediators, and the chemical reactivity of acyl chains. The present study analyzes the profile of lipid fatty acid composition of membranes of human frontal cortex area 8 in individuals ranging from 40 to 90 years old. Different components involved in polyunsaturated fatty acid biosynthesis pathways, as well as adaptive defense mechanisms involved in the lipid-mediated modulation of inflammation, are also assessed. Our results show that the lipid profile in human frontal cortex is basically preserved through the adult life span to decay at advanced ages, which is accompanied by an adaptive proactive anti-inflammatory response possibly geared to ensuring cell survival and function. Envelliment Metabolisme Àcids grassos Lòbul frontal Aging Metabolism Fatty acids Frontal lobe Lipid profile in human frontal cortex is sustained throught healthy adult lifde span to decay at advanced ages