2026-04-17T05:14:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1411192025-12-05T15:57:49Zcom_2072_1057col_2072_478860col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Lin, Crystal author Travis, Ruth C. author Appleby, Paul N. author Tipper, Sarah author Weiderpass, Elisabete author Chang Claude, Jenny author Gram, Inger T. author Kaaks, Rudolf author Kiemeney, Lambertus A. L. M. author Ljungberg, Börje author Tumino, Rosario author Tjønneland, Anne author Roswall, Nina author Overvad, Kim author Boutron-Ruault, Marie-Christine author Manciniveri, Francesca Romana author Severi, Gianluca author Trichopoulou, Antonia author Masala, Giovanna author Sacerdote, Carlotta author Agnoli, Claudia author Panico, Salvatore author Bueno de Mesquita, H. Bas author Peeters, Petra H. M. author Salamanca Fernández, Elena author Chirlaque, María Dolores author Ardanaz, Eva author Dorronsoro, Miren author Menéndez, Virginia author Luján Barroso, Leila author Liedberg, Fredrik author Freisling, Heinz author Gunter, Marc J. author Aune, Dagfinn author Cross, Amanda J. author Riboli, Elio author Key, Timothy J. author Pérez Cornago, Aurora author 2019-09-27T09:40:36Z 2019-09-27T09:40:36Z 2018-07-04 2019-09-27T09:40:36Z Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk. Càncer de bufeta Tumors Factors de risc en les malalties Bladder cancer Tumors Risk factors in diseases Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition