2026-04-14T02:28:25Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1387622025-12-04T19:28:41Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Balanzá-Martínez, Vicent author Crespo Facorro, Benedicto author González-Pinto, Ana author Vieta i Pascual, Eduard, 1963- author 2019-08-28T08:44:10Z 2019-08-28T08:44:10Z 2015-04-07 2019-08-28T08:44:10Z Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cognition, than their non-dual counterparts. Greater neurocognitive dysfunction is another facet of this severe comorbid presentation. Implications for clinical practice and research are discussed. Specifically, the application of holistic approaches, such as clinical staging and systems biology, may open new avenues of discoveries related to the BD-AUD comorbidity. Trastorn bipolar Alcoholisme Comorbiditat Manic-depressive illness Alcoholism Comorbidity Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates