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Epigenetics in the eye: an overview of the most relevant ocular diseases Alkozi, Hanan Awad Franco Fernández, Rafael Pintor, Jesús J. Epigenètica Manifestacions oculars de les malalties Epigenetics Ocular manifestations of general diseases Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye. 2019-08-01T11:14:21Z 2019-08-01T11:14:21Z 2017-10-12 2019-08-01T11:14:21Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1664-8021 https://hdl.handle.net/2445/138618 674719 29075285 eng Reproducció del document publicat a: https://doi.org/10.3389/fgene.2017.00144 Frontiers In Genetics, 2017, vol. 8, p. 144 https://doi.org/10.3389/fgene.2017.00144 cc-by (c) Alkozi, Hanan A. et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess 7 p. application/pdf Frontiers Media Articles publicats en revistes (Bioquímica i Biomedicina Molecular)