2026-04-17T13:45:33Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1384222025-12-04T21:15:58Zcom_2072_1057col_2072_478781col_2072_478917
RECERCAT
author
Zorzano Olarte, Antonio
author
Claret i Carles, Marc
2019-07-26T12:30:18Z2019-07-26T12:30:18Z2015-06-102019-07-26T12:30:18Z
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission. The importance of these events in cell physiology and pathology has been partially unraveled with the identification of the genes responsible for the catalysis of mitochondrial fusion and fission. Mutations in two mitochondrial fusion genes (MFN2 and OPA1) cause neurodegenerative diseases, namely Charcot-Marie Tooth type 2A and autosomal dominant optic atrophy (ADOA). Alterations in mitochondrial dynamics may be involved in the pathophysiology of prevalent neurodegenerative conditions. Moreover, impairment of the activity of mitochondrial fusion proteins dysregulates the function of hypothalamic neurons, leading to alterations in food intake and in energy homeostasis. Here we review selected findings in the field of mitochondrial dynamics and their relevance for neurodegeneration and hypothalamic dysfunction.
cc-by (c) Zorzano Olarte, Antonio et al., 2015 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Hipotàlem
Malalties neurodegeneratives
Mitocondris
Hypothalamus
Neurodegenerative Diseases
Mitochondria
Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion